Recurrence After Biopsy-Confirmed Cervical High-Grade Intraepithelial Lesion Followed by Negative Conization: A Systematic Review and Meta-analysis
Loading...
Date
2024-01-01
Journal Title
Journal ISSN
Volume Title
Publisher
Journal of Lower Genital Tract Disease
Abstract
The aim of the study is to assess the recurrence rate (as cervical intraepithelial neoplasia 2+ [CIN2+]) in patients who had a confirmed high-grade squamous intraepithelial lesion (CIN2–3) in a cervical biopsy specimen followed by a negative conization specimen.
Description
Materials and methods: A systematic literature review was conducted following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses checklist. Ovid/MEDLINE, Ovid/Embase, the Cochrane Central Register of Controlled Trials, and ClinicalTrials.gov were searched from inception until January 2023. The study protocol was registered in PROSPERO (ID number CRD42023393951). The search identified 3,089 articles; 1,530 were removed as duplicates, and 1,559 titles and abstracts were assessed for inclusion. The full text of 26 studies was assessed for eligibility, and finally, 12 studies with 1,036 patients were included. All included studies were retrospective cohort studies. A proportion meta-analysis was performed.
Results: For patients with negative conization specimens, the recurrence rate as CIN2+ during follow-up was 6% (95% CI, 1.8%-12.1%; I2 = 49.2; p < .0001, 215 patients and 4 studies) in the proportion meta-analysis, ranging from 0.3% to 13.0% for the individual studies. For patients with ≤CIN1 conization specimens, the recurrence rate as CIN2+ during follow-up was 3.6% (95% CI, 1.2%-7%; I2 = 75.1; p < .0001, 991 patients and 10 studies) in the proportion meta-analysis and ranged from 0.6% to 13.0% for the individual studies.
Conclusions: The recurrence rate as CIN2+ for patients with a confirmed high-grade intraepithelial lesion on a cervical biopsy followed by a negative conization specimen is 6%. In patients with negative and CIN1 conization specimens, the recurrence rate is 3.6%.
Keywords
Cervix uteri, conization, uterine cervical dysplasia
Citation
Viveros-Carreño, David MD1,2; Mora-Soto, Nathalia MD1; Rodríguez, Juliana MD3,4,5; Rauh-Hain, José Alejandro MD6; Ramírez, Pedro T. MD7; López Varón, Melissa MD6; Krause, Kate J. MD8; Grillo-Ardila, Carlos Fernando MD4; Jeronimo, Jose MD9; Pareja, René MD1,10. Recurrence After Biopsy-Confirmed Cervical High-Grade Intraepithelial Lesion Followed by Negative Conization: A Systematic Review and Meta-analysis. Journal of Lower Genital Tract Disease 28(1):p 26-31, January 2024. | DOI: 10.1097/LGT.0000000000000779