Significance of Pathologic Response in Patients With Early and Locally Advanced Breast Cancer Treated With Neoadjuvant Chemotherapy in a Middle-Income Country. A Real-World Historical Cohort
Date
2024-07-11
Journal Title
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Volume Title
Publisher
JCO Global Oncology
Abstract
PURPOSE Breast cancer (BC) is the most frequent neoplasm in women in Colombia and is
associated with a higher mortality rate than in other countries and regions.
Neoadjuvant chemotherapy (NACT) has become a standard treatment in locally
advanced BC and provides an opportunity to improve clinical outcomes in BC.
This study aims to describe characteristics, treatment patterns, and outcomes
after NACT in a cohort of Colombian patients with BC.
METHODS We performed a retrospective cohort study. We included adult patients with BC
treated with NACT. Clinical charts were retrospectively reviewed. Descriptive
statistics and time to event for overall survival analyses were performed. Recursive
partitioning was performed for survival curves to assess the complex
relationship between survival times and other variables.
RESULTS Three hundred and fourteen patients were included for analysis. The pathologic
complete response after neoadjuvant chemotherapy (ypCR) rate was 34.4%, with a
higher ypCR in triple-negative BC (TNBC; 46.9%) and human epidermal growth
factor receptor 2–positive BC (72.7%). Thosewho did not achieve ypCR had a higher
percentage of death and relapse.Themedian follow-up was 4.9 years, with an 88.2%
5-year overall survival (OS).
CONCLUSION A total of 62.6% of the total patients identified were not treated with NACT,
indicating a low utilization. Our global ypCR rate was higher when compared
with similar studies in Colombia, likely because of differences in the NACT
treatment regimens. ypCR was only associated with OS in the TNBC subgroup,
emphasizing the importance of pursuing ypCR in these patients. We consider
the use of NACT a valuable opportunity to implement innovative treatment
approaches that improve outcomes in Colombian patients with BC.
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Citation
Mantilla, W., Gonzalez, M., Rojas, S., Borras-Osorio, M., Molano-Gonzalez, N., Moran, D., Guerra, J. H., Romero, O., Munevar, I., & ICAROS Research Group. (2024). Significance of pathologic response in patients with early and locally advanced breast cancer treated with neoadjuvant chemotherapy in a middle-income country. A real-world historical cohort. JCO Global Oncology, 10(10), e2300187. https://doi.org/10.1200/GO.23.00187