Amaranto Suárez Sr. , Alejandra Beatriz Tijo López , Yuli Natalia Otero Pabon , Oscar Mauricio Forero Cuellar , Adriana Bryon Gallego2026-01-212026-01-212025-11-29https://hdl.handle.net/20.500.14595/900Vaginal clear cell carcinoma (CCC) is a rare malignant tumor in the pediatric population and may occur even in the absence of in utero exposure to diethylstilbestrol (DES). We report the case of an 11-year-old girl without DES exposure who presented with persistent foul-smelling vaginal discharge, abdominal pain, and weight loss. Imaging revealed a large vaginal mass with regional lymph node involvement. Histopathology confirmed CCC with Müllerian immunophenotype. The disease was classified as advanced and unresectable, and the patient was treated with concurrent cisplatin-based chemoradiation followed by high-dose-rate interstitial brachytherapy. She achieved significant tumor reduction and remains clinically disease-free to date. This case underscores the diagnostic complexity of pediatric vaginal CCC and supports chemoradiation with brachytherapy as an effective strategy for unresectable disease.adenocarcinoma of the vaginaadolescent girlclear cell adenocarcinomapediatrics chemotherapyradiotherapy (rt)