Leal Reina Henry SantiagoBravo Mora CatalinaRojas Angarita Paola AndreaRocha Aguirre Juan EduardoGonzález Cardona Lina Paola2026-01-212026-01-212025-09-09Bravo-Mora C, Rojas-Angarita P, Leal-Reina H, Rocha-Aguirre J, González-Cardona L. Inmunohistoquímica en cirugía micrográfica de Mohs: avances en el tratamiento del lentigo maligno en el Instituto Nacional de Cancerología de Colombia. Rev Col Cancerol. 2025;29(3):118-22.https://doi.org/10.35509/01239015.1094https://hdl.handle.net/20.500.14595/887This article describes the application of this immunohistochemistry technique in Mohs micrographic surgery for the treatment of lentigo maligna at the INC.Lentigo maligna is the most common type of melanoma in situ worldwide, characterized by significant subclinical extension and high recurrence rates following conventional surgery. For this reason, Mohs micrographic surgery is considered a first-line treatment. The use of immunohistochemistry in Mohs micrographic surgery for the treatment of lentigo maligna has proven to enhance outcomes not only in histologic evaluation but also in the speed of surgical sample processing, thereby increasing the precision and efficiency of the procedure. Consequently, its implementation began at the Functional Dermatology Unit of the Instituto Nacional de Cancerología (Colombia) (INC) in 2024. This article describes the application of this immunohistochemistry technique in Mohs micrographic surgery for the treatment of lentigo maligna at the INC.eslentigo malignamelanomaskin neoplasmsmohs micrographic surgeryimmunohistochemistryArticle