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Artículos

Permanent URI for this collectionhttps://hdl.handle.net/20.500.14595/801

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    Inmunohistoquímica en cirugía micrográfica de Mohs: avances en el tratamiento del lentigo maligno en el Instituto Nacional de Cancerología de Colombia
    (Revista Colombiana de Cancerología, 2025-09-09) Leal Reina Henry Santiago; Bravo Mora Catalina; Rojas Angarita Paola Andrea; Rocha Aguirre Juan Eduardo; González Cardona Lina Paola
    Lentigo maligna is the most common type of melanoma in situ worldwide, characterized by significant subclinical extension and high recurrence rates following conventional surgery. For this reason, Mohs micrographic surgery is considered a first-line treatment. The use of immunohistochemistry in Mohs micrographic surgery for the treatment of lentigo maligna has proven to enhance outcomes not only in histologic evaluation but also in the speed of surgical sample processing, thereby increasing the precision and efficiency of the procedure. Consequently, its implementation began at the Functional Dermatology Unit of the Instituto Nacional de Cancerología (Colombia) (INC) in 2024. This article describes the application of this immunohistochemistry technique in Mohs micrographic surgery for the treatment of lentigo maligna at the INC.
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    Metastatic Spitzoid Melanoma in a Child: Case Report
    (European Journal of Pediatric Dermatology, 2025-07-10) Paola Andrea Rojas angarita; Henry Santiago Leal Reina; Bladimir Rodriguez Lechtig; Xavier Rueda Cadena
    Spitzoid melanoma is an extremely rare and aggressive melanocytic neoplasm in childhood, and is clinically and histopathologically difficult to differentiate from other Spitzoid lesions. We present the case of a 6-year-old girl diagnosed with BRAF V600E-mutated infantile Spitzoid melanoma, metastatic to regional lymph nodes. The patient was treated with pembrolizumab (anti-PD-1) and local cryosurgery for palliative purposes, with a good initial partial response. Subsequent disease progression prompted the indication of salvage targeted therapy. She remains under multidisciplinary follow-up, has well tolerated treatment, and has not experienced visceral progression to date.This case underscores the diagnostic complexity of Spitzoid melanocytic tumors in childhood and highlights the importance of integrating histological and molecular data to guide therapeutic decisions.