Desafíos y aprendizaje: primera experiencia de fotoféresis en un niño con enfermedad de injerto contra receptor
Date
2024-07
Journal Title
Journal ISSN
Volume Title
Publisher
Asociación Colombiana de Hematología y Oncología
Abstract
Graft-versus-Host Disease (GVHD) is a serious and common complication following allogeneic
hematopoietic stem cell transplants (allo-HSCT), accounting for approximately 25% of post-transplant
deaths. Its incidence, which has increased over the past two decades, reaches around 50% in patients
undergoing allogeneic hematopoietic progenitor cell transplants. Factors such as patient age, the
use of unrelated donors, reduced-intensity regimens, and specific sources of stem cells contribute
to this increase. Initial treatment involves corticosteroids and calcineurin inhibitors, but in refractory
cases, extracorporeal photopheresis (ECP) emerges as an option. Clinical case: We present the case
of a pediatric patient undergoing haploidentical allogeneic hematopoietic progenitor cell transplant
for severe aplastic anemia, who subsequently developed severe refractory chronic GVHD, with
severe liver, skin and mild lung involvement, who underwent extracorporeal photopheresis sessions
as part of the second line of GVHD treatment, with a partial response. Conclusion: the approach
and treatment of GVHD results in the impossibility of a single treatment for all patients with this
pathology.
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Citation
Núm. 2 , Año 2024 : Julio - Diciembre